Endocrine Abstracts

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24h.Methods: Women with GDM in gestational weeks 26–32 were allocated a CGMS (IproTM2) after diagnosis in an observational prospective study. It was analysed: Mean glucose and standard deviation, area under the curve (AUC) wi...

Introduction: Silent corticotroph tumours (SCT) are a pituitary tumours (PT) subtype of corticotroph lineage that do not clinically express Cushing disease. Inmunohistochemical (IHC) studies reveal no differences between SCT and functioning corticotroph tumours with Cushing Syndrome (FCT). However, the silencing mechanisms of this type of tumours are not fully understood.Aim: In an important series of SCT, to sequence the POMC gene and quantify ...

Introduction: The last World Health Organization (WHO) 2016 classification of Pituitary Tumours recommends the determination of transcription factors. During the last few years, silent variants of the main pituitary tumours (PTs) have been described. The mechanisms of silencing of these tumors are still unknown. POU1F1 (Pit1) encodes a member of the POU family of transcription factors that has a relevant role in the differentiation, proliferation and survival of three...

Objective: Diagnosis of diabetes after transplantation (NODAT) has been described in up to 25% of cases. NODAT is a metabolically complex disorder, similar to type 2 diabetes. Factors that influence the development of NODAT are: BMI, HCV and immunosuppression. Objective: to know the prevalence and incidence of diabetes mellitus (DM) in liver transplant patients of our hospital.Patients and methods: Retrospective descriptive study of liver transplant pati...

Introduction: In type 2 diabetes the choice of the second drug after metformina is marked by the basic characteristics of the patient.Objetive: To analyze in real clinical practice the effectiveness of different antidiabetics.Material and methods: Observational study including patients with type 2 diabetes, in which we added to metformina different antidiabetics. We revised them 3-6 months from change.Results...

Introduction: Pregnancy in hypopituitary women is a rare and poorly studied clinical condition. Management difficulties and obstetrical complications have been associated with this condition.Objectives: To define the characteristics, follow-up and perinatal outcomes in hypopituitary pregnant women attended at our centre.Methods: The clinical data of the hypopituitary pregnant women (deficiency of two or more pituitary hormones), an...

Objective: Cardiovascular risk factors (CVRF) persist with notable prevalence in patients with Cushing’s disease (CD) after remission: obesity/overweight up to 40%, hypertension (HTA) up to 60%, type 2 diabetes (DM-2) up to 60% and dyslipidemia up to 30% of cases. Persistence of metabolic syndrome in patients with controlled CD seems to be related to the duration of the disease before remission. The aim of this study is to describe the prevalence of CVRF in patients with ...

Premature Ovarian Insufficiency (POI) is defined as impairement of ovarian function in women under 40 years, with a incidence between 1-4% in women of reproductive age. Among the major identified causes of Premature Ovarian Insufficiency, genetic factors related with X-chromosome are widely described. However, autosome defects are less common found and are related generally with genetic mutations instead of structural abnormalities of them. Thefor, we report a relevant case of...

A 23-year-old woman presented in May 2018 with acute left-sided hemiparesis following increasingly frequent episodes of morning drowsiness with associated weight loss. She had no significant past medical history or family history. Brain imaging excluded intracranial pathology. Blood tests during a spontaneous hypoglycaemic episode (1.5 mmol/l) identified significant hyperinsulinaemic hypoglycaemia [insulin 392 pmol/l (18–173) and C-peptide 3913 pmol/l (370–1470)]. MR...

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from parafollicular thyroid C cells that produce calcitonin, accounting for 5%-10% of thyroid cancers. In all inherited cases of MTC, and in about 40% of sporadic cases, activating mutations of the receptor tyrosine kinase proto-oncogene RET are found. Signaling pathways involved in cell proliferation, survival and motility are triggered by constitutively active RET, but the mechanisms underlying mali...